Molecular Reagent HemeScreen® DNMT3A For Research Use Only For HRM-enabled RT-PCR Machine / Cytopenia Panel 100 Tests

Features

• Precipio’s HemeScreen® offerings are Research Use Only (RUO) assays that screen for clinically actionable somatic mutations in targets of interest related to myeloproliferative disorders and haematological cancers
• The reagents are designed to be used in a clinical diagnostic laboratory by suitably trained personnel testing DNA extracted from whole blood or bone marrow using a PCR-based method and High Resolution Melt (HRM) Analysis
• DNMT3A (DNA methyltransferase 3A) mutation can be seen in AML and MDS; patients who have MDS with DNMT3A mutation have an increased chance of disease transformation to AML
• DNMT3A mutation has poor prognosis for AML patients, and can be used to monitor treatment
• Free-Flow Reagent
• Each HemeScreen® reagent sets contains enough reactions for 100 samples in duplicate and includes enough Mutant control for 5 reactions
• Reagent sets should be stored in the dark between -18 °C and -25 °C in a constant temperature freezer until use
• Machine required HRM-enabled RT-PCR (example/ ThermoFisher Quantstudio 3 or higher)

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