Product Comparison


  Sagent Pharmaceuticals 25021083082 Dr. Reddy's Laboratories 55111068852 NorthStar Rx 16714081501 Amgen Inc (Oncology) 55513073001 Amgen Inc 55513071001
McKesson # 872946 835520 1128120 742959 729015
Description Zoledronic Acid / Mannitol-Water 5 mg / 100 mL Injection Flexible Bag 100 mL Zoledronic Acid / Mannitol-Water 5 mg / 100 mL Injection Infusion Bottle 100 mL Zoledronic Acid 4 mg / 5 mL Concentrate Injection Single-Dose Vial 5 mL Xgeva® Denosumab, Preservative Free 120 mg Injection Single-Dose Vial 1.7 mL Prolia® Denosumab, Preservative Free 60 mg / mL Injection Prefilled Syringe 1 mL
Manufacturer # 2502108308255111068852167140815015551307300155513071001
Brand    Xgeva®Prolia®
Manufacturer Sagent PharmaceuticalsDr. Reddy's LaboratoriesNorthStar RxAmgen Inc (Oncology)Amgen Inc
Invoice ZOLEDRONIC ACID, PGBCK 5MG/100ML 100MLZOLEDRONIC ACID, SDV 5MG 100MLZOLEDRONIC ACID, SDV 0.8MG/ML 5MLXGEVA, SDV PF 120MG/1.7ML 1.7MLPROLIA, SYR 60MG/ML 1M
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Comparison

Alternate Manufacturer Number 1904341201722639061871925965
Container Type Flexible BagInfusion BottleSingle-Dose VialSingle-Dose VialPrefilled Syringe
Country of Origin UnknownIndiaUnknownSingaporeSingapore
Generic Drug Code 3422825026194762926128656
Generic Drug Name Zoledronic Acid / Mannitol-WaterZoledronic Acid / Mannitol-WaterZoledronic AcidDenosumab, Preservative FreeDenosumab, Preservative Free
NDC Number 2502108308255111068852167140815015551307300155513071001
Product Dating McKesson Acceptable Dating: we will ship >= 90 daysMcKesson Acceptable Dating: we will ship >= 90 daysMcKesson Acceptable Dating: we will ship >= 90 daysMcKesson Acceptable Dating: we will ship >= 180 daysMcKesson Acceptable Dating: we will ship >= 180 days
Storage Requirements Requires RefrigerationRequires Refrigeration
Strength 5 mg / 100 mL5 mg / 100 mL4 mg / 5 mL Concentrate120 mg60 mg / mL
Type IntravenousIntravenousIntravenousSubcutaneousSubcutaneous
UNSPSC Code 5118241551182415511824155118242851182428
User Adult
Volume 100 mL100 mL5 mL1.7 mL1 mL
Application Bone Resorption InhibitorBone Resorption InhibitorBone Resorption InhibitorBone Resorption InhibitorBone Resorption Inhibitor
Dosage Form InjectionInjectionInjectionInjectionInjection
Features and Benefits
  • Ready-to-use formulation
  • Zoledronic acid injection is a bisphosphonate indicated for the treatment of: Hypercalcemia of malignancy, multiple myeloma and bone metastases from solid tumors
  • The zoledronic acid injection infusion time must not be less than 15 minutes given over a constant infusion rate
  • Zoledronic acid injection must not be mixed with calcium or other divalent cation-containing infusion solutions, such as Lactated Ringer’s solution, and should be administered as a single intravenous solution in a line separate from all other drugs
  • Infusion bottle with built-in plastic hanger
  • One bottle with 100 mL solution contains 5.330 mg of zoledronic acid monohydrate, equivalent to 5 mg zoledronic acid on an anhydrous basis
  • Inactive Ingredients: 4950 mg of mannitol, USP; and 30 mg of sodium citrate, USP
  • Not for Direct Injection
  • Prolia® (denosumab) is indicated for the treatment of postmenopausal women with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy
  • Prolia is indicated as a treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for nonmetastatic prostate cancer
  • Prolia is indicated as a treatment to increase bone mass in women at high risk for fracture receiving adjuvant aromatase inhibitor therapy for breast cancer
  • All patients should receive calcium 1000 mg daily and at least 400 IU vitamin D daily
  • Pre-existing hypocalcemia must be corrected prior to initiating Prolia®
  • Administer 60 mg every 6 months as a subcutaneous injection in the upper arm, upper thigh, or abdomen
  • Each 1 mL single-use prefilled syringe of Prolia contains 60 mg denosumab (60 mg/mL solution), 4.7% sorbitol, 17 mM acetate, 0.01% polysorbate 20, Water for Injection (USP), and sodium hydroxide to a pH of 5.2
  • Store Prolia in a refrigerator at 2°C to 8°C (36°F to 46°F) in the original carton
  • Protect Prolia from direct light and heat